Dystroglycan Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2B1G12, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66735-1-IG-150UL

Product Code. 16898885

Description

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Specifications

• Antigen: Dystroglycan
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q14118, Q29243, Q62165
• Gene Symbols: Dag1
• Immunogen: Dystroglycan Fusion Protein Ag27222
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Porcine, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 2B1G12
• Conjugate: Unconjugated
• Gene: DAG1
• Gene Alias: 156DAG, A3a, AGRNR, Alpha DG Beta dystroglycan, Beta DG, DAG, DAG1, Dystroglycan
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100620392, 114489, 13138, 1605
• Content And Storage: -20°C
• Form: Liquid