Alpha E catenin Mouse anti-Human, Mouse, Clone: 2B7B8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66221-1-IG-150UL

Product Code. 16877895

Description

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Specifications

• Antigen: Alpha E catenin
• Classification: Monoclonal
• Concentration: 2.08 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P26231, P35221
• Gene Symbols: CTNNA1
• Immunogen: Alpha E catenin Fusion Protein Ag23603
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 2B7B8
• Conjugate: Unconjugated
• Gene: CTNNA1
• Gene Alias: Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 12385, 1495
• Content And Storage: -20°C
• Form: Liquid