Invitrogen™ Human IKK beta (C3) Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP0042

Product Code. 15256269

Description

IKK beta (C3) Synthetic Peptide, PEP-0042, from Invitrogen.

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15). This peptide corresponds to 19 amino acids near the carboxy terminus of human IKK beta (C3).PEP-0042 can be used as a blocking peptide with polyclonal antibody PA5-19916.

Specifications

• Gene ID (Entrez): 3551
• Purification Method: purified
• Common Name: Human IKK beta (C3)
• Content And Storage: -20°C
• Format: Liquid
• For Use With (Application): Blocking Assay, Control
• Lyophilized: No
• Product Type: Peptide
• Regulatory Status: RUO - research use only

• Species: Human
• Accession Number: O14920
• Concentration: 200 μg/mL
• Description: Synthetic Peptide
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• Gene Symbol: IKBKB
• Preservative: 0.02% sodium azide
• Quantity: 50 μg
• Storage Buffer: PBS