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GABA-A Receptor gamma Polyclonal Antibody, Invitrogen™

GABA-A Receptor gamma Antibody, PA1-4687, from Invitrogen™. Species Reactivity: Ms, Rt; Applications: DB, IHC (Frozen), Immunoprecipitation, Western Blot.

Brand:  Invitrogen PA14687

Code : LD

Additional Details : Weight : 0.01000kg

Product Code. 11593491

  • £266.00 / 100µL

Estimated Shipment date
from Supplier 13-01-2020

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Description

Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date, 6 alpha, 4 beta and 4 gamma, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). More recently there have been a number of studies demonstrating that the delta-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).
Host Species: Rabbit
Cross Reactivity: Mouse, Rat
Isotype: IgG
Immunogen: Fusion protein from the N-terminal region of the delta subunit of rat GABRD
Formulation: 100μL purified antibody in 0.01M HEPES with 0.15M NaCl, 100µg/ml BSA, 50% glycerol and no preservative; pH 7.5
Synonyms: GABA(A) receptor subunit gamma-1protein 1, GABA(A) receptor subunit gamma-1 GABA(A) receptor subunit gamma-1protein 1, GABA(A) receptor subunit gamm
Uniprot Accession: P18506, P22933
Entrez GeneID: 14403, 29689
Gene Symbol: GABRD
This antibody is specific for the ∽52 kDa d-subunit of the GABA-A receptor.
Specifications

Specifications

GABA-A Receptor gamma
Polyclonal
100μL purified antibody in 0.01M HEPES with 0.15M NaCl, 100µg/ml BSA, 50% glycerol and no preservative; pH 7.5
Purified
GABRD
Fusion protein from the N-terminal region of the delta subunit of rat GABRD
100μL
Store at -20°C, Avoid Freeze/Thaw Cycles
Primary
14403, 29689
Dot Blot, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Unconjugated
P18506, P22933
GABA(A) receptor subunit gamma-1protein 1, GABA(A) receptor subunit gamma-1 GABA(A) receptor subunit gamma-1protein 1, GABA(A) receptor subunit gamm
Rabbit
IgG
RUO
Primary
Polyclonal
Murine, Rat
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