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Epstein Barr Virus Mouse anti-Virus, Clone: 4A8, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA122678

Code : LD

Additional Details : CAS Number : 69-74-9 Weight : 0.01000kg

Product Code. 11581370

  • £288.00 / 100µg

Estimated Shipment date
from Supplier 14-01-2020

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Description

Description

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin′s disease and Burkitt′s Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all maligcies associated with EBV.
Specifications

Specifications

Epstein Barr Virus
Monoclonal
2 mg/mL
PBS with 0.1% sodium azide; pH 7.4
EBV
Hybridization of Sp2/0 myeloma cells with spleen cells of a Balb/c mice immunized with purified EBV
Protein G
RUO
Antibody
Monoclonal
Immunocytochemistry, Immunofluorescence
4A8
Unconjugated
Liquid
Mouse
IgG2b
100 μg
4° C
Primary
Virus
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